JYarba
Google
La Mision might be the nicest hotel in Paraguay. Sitting in the affluent neighborhood of Recoleta (although some say it's in Villa Morra, a minor quibble since Villa Morra is also safe and affluent), its location is walkable to plenty of great restaurants and shopping. If you want the downtown sights, though, you'll need to take a car. I had no trouble finding Bolt rides when I wanted to go further afield, and Uber is apparently pretty well-embedded in Asuncion as well. I'd also recommend you take these services from the airport as well if you don't rent your own car like I did; it's about 30 minutes away, but the shuttle the hotel offered me was a stunning $60. Room cleanliness and design are on-par with highly-regarded boutique hotels anywhere else in the world. Service is over-the-top with attentiveness and pleasant interactions, from the security guard outside right on up to the managers. The door was held for me every time I came in or went out. When my flight landed too early to get an immediate check-in, the front desk clerk gave me advice on options to pass the time and then upgraded me when my room still wasn't ready after check-out time passed. English was well-spoken by all front desk staff and decently well by restaurant staff; you may need a little Spanish if you need to interact with the housekeepers. Honestly, it pains me to dock any stars from this hotel; only two minor issues keep it from a perfect rating, neither of which are the fault of its staff. First, the price point is just too high--at over $200 a night for the most basic room, it's far above the cost of other very nice properties in the area. Second, as an old building it lacks some of the quietness of modern constructions--there are frequent creaks and groans from pipes and elevators, and if you're a light sleeper street and construction noise may be an issue. If there was an option for 4.5 stars that's where I would settle.