Jo N.
Yelp
I have to tell you, reading some of the other online reviews of Locanda di Palazzo Cicala is making me very nervous but my personal experience last Sept. was good.  First of all, be forewarned, Genova--in particular the historic city center--is a dangerous place. Many areas of Genova, such as the historic center, supersede the absolute worst neighborhoods of NYC.  I personally never liked Genova as a whole, but my family lives there so I go.... (Plus I LOVE the authentic focaccia LOL.)
I can't recall my room number at Locanda di Palazzo Cicala but it was very nice and it was INSIDE the actual building in Piazza San Lorenzo 16, next to the historic Cathedral of San Lorenzo.  There was No shuffling around to other buildings/properties for me! 
My room was lovely; obviously historic, very large with these very high 17th century ceilings and antiques. The ceilings and partial fresco's that remained from the 17th century were just lovely. I loved being able to stay in such a historic space even if just for a few days. The space was quiet with a view of San Lorenzo. Parts of the hotel were historic while other parts were ultra modern looking. The customer service was OK; I had no problems. And the hotel itself was conveniently located to restaurants, locales, the historic center etc. I wouldn't mind staying here again.