"Set in an enviable location within the centro storico, Anantara Palazzo Naidi’s 232 guest rooms and suites feel like mini palaces, with their enormous beds, neutral-toned decor, and in some cases, personal whirlpools. Accommodations at the front of the hotel face Piazza della Repubblica’s crescent-shaped colonnades, a fountain of bathing nymphs (naiads), and Baths of Diocletian. Ancient Rome’s thermal spa healing traditions, along with Ayurvedic rituals and Asian treatments, come together at Anantara’s signature spa, while executive chef Heros de Agostinis curates the menu at fine dining restaurant Ineo. La Fontana, located on the first level, is a piazza-facing dining hall, while the open-air rooftop is home to Seen restaurant, which focuses on Japanese Brazilian cuisine. The hotel collaborated with Casa Manfredi, Rome’s best pastry shop, for a ground-level outpost that stocks mont blancs and jolies (Chantilly cream–filled macarons). From $640" - Erica Firpo, Laura Itzkowitz