"Housed in a historic turn-of-the-20th-century building renovated to include nearly 10,500 square feet of exhibition space, 21c Museum Hotel is equal parts art gallery and modern lodging. Guests and the public will find a range of programs, from solo and group shows to rotating installations, curated by Alice Gray Stites. You’ll also find a touch of whimsy in the form of the brand’s signature penguin sculptures, a playful gesture that extends to the guest rooms. Featuring light hardwood floors, white walls, and colorful modern furnishings, they serve as a coordinating backdrop for original works by local artists; flat-screen televisions, Nespresso coffee makers, and Malin + Goetz bath amenities keep things comfortable. Downstairs, the chef at Gray & Dudley transforms ingredients from neighborhood markets and farms into dishes like pan-roasted duck breast with apple purée and black-eyed pea falafel. Another must-try indulgence? The small spa requires 24-hour advance reservations, but the calm respite after a day of sightseeing makes it worth the wait."