"Casa Iris must be the only bed and breakfast in the world to share a renovation team with the Sistine Chapel. Located in southern Tuscany in Orbetello, a peninsula surrounded by a lagoon, the B&B is a 16th century palazzo owned by stylist James Valeri and his husband Matthew Adams. After the house, which has been in Valeri's family for a century or so, was bought by the couple, they left New York's East Village for Italy to turn the palazzo into the perfect B&B." - Mark Holgate