"With sleek 1920s decorations in a hidden, speakeasy-inspired space, Handshake offers a cocktail menu by award-winning Dutch bartender Eric Van Beek. Known for drinks like a clarified piña colada, along with takes on modern classics like the pornstar martini, the bar won the top spot in North America on the 50 Best Bars list in 2024. The basement, where a cocktail lab produces syrups, clarified juices, and other beverage magic, also seats guests, and you should jump at the opportunity to drink down there if you get the chance. As of late, reservations are challenging, so plan ahead with a reservation. Know before you go: The Handshake cocktail experience lasts strictly two hours and allows you to enjoy about three to four rounds of drinks, so show up on time to get the most out of your reservation." - Natalia de la Rosa