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"As the most popular Eurail journey of 2025 for American travelers, this route links two vibrant cultural hubs, running from Santa Maria Novella to Roma Termini; it reflects how many time‑pressed U.S. visitors gravitate to buzzy connections between Italy’s art cities." - Iona Brannon Iona Brannon Iona Brannon is a journalist with a love for food and travel. Her work has appeared in Afar, Bon Appétit, Condé Nast Traveler, Travel + Leisure, and Business Insider, among other publications. Travel + Leisure Editorial Guidelines
Main Florence railway station; serves 59 million passengers yearly
Piazza della Stazione, 50123 Firenze FI, Italy Get directions