Hilton Molino Stucky Venice

"Set on Venice's Giudecca Island, this 379-room hotel has come a long way since its days as a flour mill: With the second largest spa in the city, plus a rooftop pool and seven restaurants and bars, there's little about it that's underwhelming. After a full day of sightseeing (or an especially long flight), you'll want to head to the Eforea Spa, where you can take in an Enhancement, Escape, or Essential treatment (designed by the British brand ELEMIS) by one of the on-staff beauty therapists. Just don't fall asleep: You'll want to hit the sauna, steam bath, and Jacuzzi afterwards."