The Best Hotels in Napa Valley, From a Stagecoach Stop-Turned-Boutique Hotel to a Luxe Italian-Inspired Stay

"Located within downtown Napa's First Street, a 325-square-foot multi-use development with more than two dozen specialty boutiques, restaurants, and tasting rooms, think of this 183-room hotel as your home base to the Valley. Opened in 2017, the hotel features an upscale steakhouse, Charlie Palmer; a rooftop spa; a robust art program with works by local and regional artists curated by New York art advisor Deborah Goodman Davis; and guest rooms and suites in six different layout configurations ranging from 285 square feet to 780 square feet. After a day at play exploring nearby wineries or a hot air balloon excursion (the concierge can arrange either), head upstairs to the open-air restaurant and bar, Sky & Vine Rooftop Bar, for a cocktail and sunset-watching by a firepit." - Jennie Nunn