Just 75 miles south of Memphis, Clarksdale is considered the cradle of the Delta blues. At the heart of it all is Ground Zero Blues Club, co-founded by actor Morgan Freeman and beloved by blues aficionados from around the world. The club offers live music every week and an atmosphere thick with history and grit—Rolling Stone and Condé Nast Traveler both recommend it for its authentic performances and deep ties to local musicians. The surrounding town is dotted with murals, juke joints, and the Delta Blues Museum, making for a full, soulful day steeped in musical heritage.