Bristol Panama, a Registry Collection Hotel

"Situated in the Calle Uruguay business district, the Bristol Panama has epitomized style and elegance for over twenty years. The 56 rooms and suites all feature Frette linens and mahogany furnishings, plus bathrooms outfitted in Italian marble. Named for a famous—some would say notorious—local street, the art-filled Salsipuedes Cocina & Bar is considered one of the best in the city for its contemporary Panamanian fare. The restaurant also houses a first-rate bar with 70 rums, including 12 from Panama alone—try the well-regarded Ron Abuelo Añejo 15 años, available in sherry, port, and cognac cask finishes. When guests want to relax, they can head to the large outdoor pool and solarium, or book a massage at the hotel spa, which incorporates aspects of lomi lomi, shiatsu, and Thai stretching into its many treatments."