6th & Vine Restaurant and Wine Bar

The Best Restaurants in Winston-Salem, North Carolina | Eater Carolinas

"Tucked into the Arts District, 6th & Vine has been a neighborhood staple since 2005, offering a laid-back wine bar experience with Southern flavors and global influences. Owner Kathleen Barnes keeps the spot thriving, with a handcrafted bar — built by her father — anchoring the cozy interior. A lush garden patio adds to the charm, while the menu features favorites like baked brie in pastry, sesame-crusted ahi tuna with Thai chili slaw, and chorizo-laced shrimp and grits in Cajun white wine sauce. It remains a perennial downtown favorite with deep roots, a well-curated wine list, and a lively yet intimate vibe." - Nikki Miller-Ka