2

Guadalupe On Main

Restaurant · Mesa ·

Guadalupe On Main

Restaurant · Mesa ·
@postcardnews
22,027 Postcards · 1,950 Cities

A fresh chapter in a beloved space, this newcomer blends Jalisco staples like carnitas and mole with playful additions and a strong cocktail program. Phoenix New Times’ first look praised the mushroom “calamari,” rich braises, and customizable margaritas.

https://www.phoenixnewtimes.com/restaurants/new-mesa-restaurant-guadalupe-on-main-serves-mexican-food-with-flair-20616092
Best Restaurants in Mesa (2025)
View this post on Instagram

Information

Gluten-free Mexican cuisine, craft cocktails, and attentive staff

gluten-free options
mole enchiladas
birria tacos
churros
craft cocktails
atmosphere
carne asada
delicious food
Google Rating
4.7 (670)
Yelp Rating
4.6
Placeholder

1526 E Main St, Mesa, AZ 85203 Get directions

$20–30

See Menu
Restroom
Accepts reservations
Popular for lunch
Popular for dinner
Dinner reservations recommended
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
See full details

2

Information

Gluten-free Mexican cuisine, craft cocktails, and attentive staff

gluten-free options
mole enchiladas
birria tacos
churros
craft cocktails
atmosphere
carne asada
delicious food
Google Rating
4.7 (670)
Yelp Rating
4.6
Placeholder

1526 E Main St, Mesa, AZ 85203 Get directions

$20–30

See Menu
Restroom
Accepts reservations
Popular for lunch
Popular for dinner
Dinner reservations recommended
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
Guadalupe On Main by null
See full details

More Places For You

Jalapeño Buck's

Barbecue restaurant · Mesa

Hearty BBQ plates & PBJ brisket sandwiches; walk-up joint

2 Postcards

The Stone Korean Tofu House

Korean restaurant · Mesa

House-made tofu, bubbling stews, and varied banchan sides

3 Postcards

P.F. Chang's

Chinese restaurant · Mesa

Creative Asian fare with attentive service and allergy-friendly options

1 Postcard

Dad's Garage

Auto repair shop · Mesa

Honest, friendly, and reliable auto repair with fast service

0 Postcards

Arizona Distilling Co.

Distillery · Mesa

Craft distillery serving award-winning spirits, cocktails, & food

1 Postcard

What’s Crackin Cafe

Brunch restaurant · Mesa

Eclectic breakfast & lunch, happy hour, patio, and seafood

2 Postcards

Orange Patch Too

Gift shop · Mesa

Fresh citrus, local produce, boutique gifts, decor, and snacks

1 Postcard

Chick-fil-A

Fast food restaurant · Mesa

Fast-food chicken chain serving sandwiches, nuggets, salads, and sides.

5 Postcards

Extended Stay America Suites- Phoenix - Mesa

Extended stay hotel · Mesa

Rooms with kitchens, free Wi-Fi, and breakfast.

1 Postcard

Main Burger

Restaurant · Mesa

Smashed patties, green chile & ham Chiwas burger, Sonora burger

2 Postcards